Creating advanced models to study immune responses using 3D printed tissue systems
Multi-organ culture and pumping systems for ex vivo models of immunity in hybrid tissue-chips
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-10890580
This study is exploring new 3D printed models that mimic how lymph nodes work with other organs to help us learn more about how our immune system fights infections, responds to vaccines, and deals with tumors, which could lead to better vaccines and treatments for autoimmune diseases and cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10890580 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative 3D printed microfluidic systems that simulate the interactions between lymph nodes and surrounding organs. By creating these hybrid tissue-chips, researchers aim to better understand how our immune system responds to infections, vaccines, and tumors. The approach involves precise control of fluid flow and circulation of immune cells, allowing for detailed studies of immune function and disease mechanisms. This could lead to improved vaccine designs and therapies for autoimmune diseases and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that affect immune responses, such as autoimmune diseases or cancer.
Not a fit: Patients with stable, non-immune related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses, leading to better vaccines and treatments for various diseases.
How similar studies have performed: Previous research has shown promise in using microfluidic systems for studying immune interactions, indicating potential success for this novel approach.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POMPANO, REBECCA R — UNIVERSITY OF VIRGINIA
- Study coordinator: POMPANO, REBECCA R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.