Creating advanced models of Alzheimer's disease and related dementias
Alzheimer's Disease-Related Dementia Models by Precision Editing and Relevant Genetic x Environmental Exposures
This study is creating special mice with different genes to help us learn more about Alzheimer's disease and related dementias, so we can find better ways to diagnose and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-10913636 on NIH RePORTER |
What this research studies
This research focuses on developing genetically diverse mouse models that accurately represent Alzheimer's disease and related dementias. By using precise genomic editing techniques like CRISPR/Cas9, the researchers will introduce specific mutations associated with these conditions into the mice. The study aims to understand how different genetic backgrounds influence the risk and resilience to Alzheimer's and related dementias, which could lead to better diagnostic and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or related dementias, as well as those showing early signs of cognitive decline.
Not a fit: Patients with non-genetic forms of dementia or those without any familial link to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown success in using genetically modified animal models to study Alzheimer's disease, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: O'connell, Kristen M — Jackson Laboratory
- Study coordinator: O'connell, Kristen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.