Creating advanced imaging tools to improve immunotherapy outcomes
Developing Multimodal Multiplexed ImmunoPET-Raman Probes to Guide Immunotherapies
['FUNDING_R01'] · IOWA STATE UNIVERSITY · NIH-10836337
This study is looking at new ways to use special imaging techniques to help doctors see important immune markers in patients getting immunotherapy, so they can better understand who will benefit most from their treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | IOWA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (AMES, UNITED STATES) |
| Trial ID | NIH-10836337 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative imaging probes that can simultaneously detect multiple immune markers, including PD-L1 and CD8+ T cells, in patients undergoing immunotherapy. By using advanced techniques like ImmunoPET and Raman spectroscopy, the study aims to provide a noninvasive method for accurately identifying which patients are likely to benefit from specific immunotherapies. This approach addresses the limitations of current diagnostic methods that often fail to predict treatment responses due to variability in testing. Ultimately, the goal is to enhance patient selection for immunotherapy, leading to better treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with cancers that are treated with PD-1/PD-L1 inhibitors, particularly those who have not responded to standard therapies.
Not a fit: Patients who are not undergoing immunotherapy or those with conditions unrelated to the PD-1/PD-L1 pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the ability to identify patients who will respond to immunotherapy, leading to more effective and personalized treatment plans.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for single immunomarker detection, but this approach to multiplexing is novel and untested.
Where this research is happening
AMES, UNITED STATES
- IOWA STATE UNIVERSITY — AMES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARDHAN, RIZIA — IOWA STATE UNIVERSITY
- Study coordinator: BARDHAN, RIZIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.