Creating advanced imaging techniques to study the 3D organization of genes
Official title: Developing next-generation high-content image-based genetic screens for multi-omic spatial phenotypes
Funded at Yale University · NIH-10856698 · Data updated 2026-11-12
This study is looking at how genes are arranged in 3D space inside our cells using new imaging technology, which could help us understand more about gene behavior and how it relates to different diseases, ultimately benefiting patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 17, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $653,880 |
| NIH project number | 1R01HG013503-01 |
| Project ID | NIH-10856698 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or conditions influenced by gene regulation.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or those not affected by cellular organization may not receive direct benefits from this research.
What this research studies
This research focuses on developing innovative imaging technologies that utilize CRISPR to explore how genes are organized in three-dimensional space within cells. By creating a high-content, image-based screening platform, the project aims to identify the molecular regulators that control this spatial organization, which is crucial for understanding cellular functions. Patients may benefit from insights gained about gene regulation and its implications for various diseases, as the research seeks to uncover new mechanisms of gene expression and cellular behavior. The approach combines multiple techniques to provide a comprehensive view of how genes interact and function within their spatial context.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic regulation and its impact on diseases, potentially informing new treatment strategies.
How similar studies have gone: Other research has shown success with CRISPR-based approaches in gene regulation, indicating that this innovative method has the potential for significant advancements.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Wang, Siyuan — Yale University
- Study coordinator: Wang, Siyuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.