Creating advanced human tissues using engineered organoids
Integration of Systems and Synthetic Biology to Advance Development of Human Tissues In Vitro
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11072034
This study is working on creating tiny versions of human organs from stem cells to help scientists better understand how our bodies develop and how diseases work, which could eventually improve treatments for conditions like organ failure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11072034 on ClinicalTrials.gov |
What this research studies
This research focuses on developing human organoids, which are miniaturized and simplified versions of organs created from induced human pluripotent stem cells. By utilizing synthetic and systems biology, the project aims to enhance the self-organization and differentiation processes of these organoids, making them more reliable for studying tissue development and disease. The approach involves using computational models and genetic technologies to engineer organoids that can better mimic natural biological processes. This could lead to significant advancements in regenerative medicine and organ transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who may benefit from advancements in organ transplantation or those with conditions requiring tissue regeneration.
Not a fit: Patients with conditions that do not involve tissue regeneration or organ transplantation may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for creating human tissues for transplantation and disease modeling.
How similar studies have performed: Previous research has shown promise in using organoids for studying organ development and disease, indicating that this approach has potential for success.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EBRAHIMKHANI, MO REZA — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: EBRAHIMKHANI, MO REZA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.