Creating advanced human intestinal models from stem cells
Official title: Human iPSC intestine mimetics with integrated mesenchymal, endothelial and enteric nervous tissue
Funded at University of Michigan at Ann Arbor · NIH-11039916 · Data updated 2026-11-12
This study is working on creating a mini version of the human intestine using special stem cells, which could help us learn more about how the intestine develops and how to better treat intestinal disorders that affect patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $475,115 |
| NIH project number | 5R01DK137806-02 |
| Project ID | NIH-11039916 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with intestinal disorders or those interested in advancements in gastrointestinal health.
✕Less likely to help
Patients with non-intestinal related health issues may not receive any benefit from this research.
What this research studies
This research focuses on developing a sophisticated model of the human intestine using induced pluripotent stem cells (iPSCs). The team has successfully created a three-dimensional intestinal organoid that includes various cell types such as epithelial cells, smooth muscle, endothelial cells, and enteric neurons. By using specific growth factors and innovative culture techniques, they aim to enhance the complexity and functionality of these organoids, which could provide insights into intestinal development and disease. Patients may benefit from this research as it could lead to better understanding and treatment of intestinal disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for various intestinal diseases and conditions.
How similar studies have gone: Other research has shown promise in using stem cell-derived organoids for studying various diseases, indicating a potential for success in this novel approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Spence, Jason — University of Michigan at Ann Arbor
- Study coordinator: Spence, Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.