Creating advanced human ear models to study hearing loss
Engineering High-Fidelity Human Cochlear Organoids
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10868452
This study is working on creating tiny, lab-grown versions of the inner ear to learn more about hearing loss and find new ways to help people who have lost their hearing due to damaged hair cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10868452 on ClinicalTrials.gov |
What this research studies
This research focuses on developing high-fidelity human cochlear organoids to better understand and potentially restore hearing loss caused by the loss of sensory hair cells in the cochlea. The team will utilize human pluripotent stem cells to create 3D cultures that mimic the inner ear's structure and function. By employing genetic programming and CRISPR technology, they aim to enhance the production of cochlear hair cells and establish connections with the brain's auditory pathways. This innovative approach could lead to breakthroughs in treating hearing impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing hearing loss due to damage to cochlear hair cells.
Not a fit: Patients with hearing loss caused by non-sensory factors, such as auditory nerve damage or central auditory processing disorders, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore hearing by regenerating damaged sensory cells in the inner ear.
How similar studies have performed: Previous research has shown promise in using organoid systems for studying auditory development, but this specific approach is novel and aims to enhance existing methodologies.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HASHINO, ERI — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: HASHINO, ERI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.