Creating advanced glycan microarrays using light-sensitive chemical groups
Official title: Chromatically Orthogonal Photolabile Protecting Groups for the Parallel On-Chip Synthesis of High-Density Glycan Microarrays
Funded at Iowa State University · NIH-10891709 · Data updated 2026-11-12
This study is working on a new way to create tiny chips that can help scientists learn more about how sugars in our bodies interact with proteins and germs, which could lead to better tests and treatments for various health conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $205,151 |
| NIH project number | 5R21GM151612-02 |
| Project ID | NIH-10891709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with conditions related to carbohydrate metabolism or those requiring advanced diagnostic testing for glycan interactions would be ideal candidates.
✕Less likely to help
Patients who do not have carbohydrate-related conditions or who are not involved in research studies on glycan interactions may not benefit from this research.
What this research studies
This research focuses on developing new methods to create high-density glycan microarrays, which are tools used to study carbohydrates and their interactions. By using different wavelengths of light and special chemical groups that can be activated by light, the researchers aim to build complex carbohydrate structures on a microchip. This approach allows for the simultaneous synthesis of multiple glycan structures, which can then be used to identify how different proteins, antibodies, and pathogens interact with these carbohydrates. The goal is to enhance our understanding of glycan biology and improve diagnostic and therapeutic applications.
Why it matters
Potential benefit: If successful, this research could lead to more effective diagnostic tools and therapies targeting carbohydrate-related diseases.
How similar studies have gone: While the approach of using light-sensitive chemical groups is innovative, similar methods have shown promise in other areas of microarray technology, indicating potential for success.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Winter, Arthur H. — Iowa State University
- Study coordinator: Winter, Arthur H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.