Creating advanced genetic tools to study blood stem cells
Developing Next Generation Genetics for Understanding Hematopoietic Stem Cell Biology
This study is working on new genetic tools to help scientists learn more about blood stem cells in the bone marrow, which are important for making all types of blood cells and for successful bone marrow transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10871899 on NIH RePORTER |
What this research studies
This research focuses on developing innovative genetic tools using Cre recombinase and Cas9 nuclease to better understand hematopoietic stem cells (HSCs) in the bone marrow. By enabling precise control of gene expression and lineage tracing, the project aims to investigate how the adult HSC pool is established in vivo. This understanding is crucial as HSCs are responsible for producing all blood cell types and are vital for successful bone marrow transplants. The new tools will allow researchers to trace HSCs at the clonal level, potentially leading to significant advancements in both basic biology and clinical applications.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals undergoing or considering bone marrow transplantation or those with blood-related conditions.
Not a fit: Patients with conditions unrelated to hematopoietic stem cells or those not requiring blood cell therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for bone marrow transplantation and treatments for blood disorders.
How similar studies have performed: Other research has successfully utilized genetic tools for studying stem cells, indicating a promising potential for this novel approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Yazawa, Masayuki — Icahn School of Medicine at Mount Sinai
- Study coordinator: Yazawa, Masayuki
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.