Creating advanced genetic tools for studying diseases in zebrafish
Official title: Conditional genetics and precision genome editing resources for Zebrafish
Funded at Iowa State University · NIH-10849079 · Data updated 2026-11-12
This study is exploring how we can use zebrafish to better understand human health and diseases by creating special tools that let us control genes in specific parts of the fish at certain times, which could help us learn more about how diseases work and how to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,023,185 |
| NIH project number | 1R24OD036201-01 |
| Project ID | NIH-10849079 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in genetic studies related to human health, particularly those with conditions that could benefit from insights gained through animal model research.
✕Less likely to help
Patients who are not interested in or do not have conditions that can be modeled in zebrafish may not receive direct benefits from this research.
What this research studies
This research focuses on developing new genetic resources and tools to better understand human health and diseases using zebrafish as a model organism. By utilizing advanced genome editing techniques, such as CRISPR, the project aims to create conditional gene modifications that allow for precise control of gene expression in specific tissues and at specific times. This approach will enhance the ability to study complex biological processes and disease mechanisms in a living organism, providing insights that could translate to human health applications.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for various human diseases by leveraging zebrafish as a model system.
How similar studies have gone: Previous research using zebrafish as a model organism has shown significant success in understanding various biological processes and diseases, indicating that this approach is both promising and well-established.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Mcgrail, Maura a. — Iowa State University
- Study coordinator: Mcgrail, Maura a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.