Creating advanced cell therapies to improve treatment outcomes for chronic diseases
Official title: Engineering cell-based therapy for enhanced survival and durable function in vivo
Funded at Mayo Clinic Arizona · NIH-11143150 · Data updated 2026-11-12
This study is exploring new ways to use specially engineered cells to create lasting treatments for conditions like hemophilia, diabetes, and liver disorders, so patients can enjoy better health without needing constant therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $416,250 |
| NIH project number | 5R35GM155031-02 |
| Project ID | NIH-11143150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic diseases such as hemophilia, diabetes, or liver disorders who may benefit from advanced cell-based therapies.
✕Less likely to help
Patients with acute conditions or those who do not have chronic diseases may not receive any benefit from this research.
What this research studies
This research focuses on developing innovative cell-based therapies that can provide long-lasting treatment for chronic conditions like hemophilia, diabetes, and liver disorders. The approach involves engineering cells that can secrete therapeutic proteins and encapsulating them to protect against the body's immune response. By addressing challenges such as immune activation and cellular dysfunction, the research aims to create a reliable method for transplanting these engineered cells without the need for systemic immunosuppression. Patients may benefit from a more effective and durable treatment option that could reduce the need for ongoing therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective and long-lasting treatments for chronic diseases, improving patients' quality of life.
How similar studies have gone: While there has been significant research in cell-based therapies, this specific approach of combining engineered cells with encapsulation to enhance long-term function is relatively novel and has not yet been fully realized in humans.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Bose, Suman — Mayo Clinic Arizona
- Study coordinator: Bose, Suman
Related research
Other NIH-funded projects on the same topics.
-
Predicting Pain Recovery with a Multimodal AI using Harmonized Health Records
Aging patients with headaches will be helped by a new AI tool that uses medical records and brain images from Mayo Clinic and VA to predict who might have persistent pain.
-
Understanding immune signals in ALS to guide future therapies
A Mayo Clinic team will study how the immune system sees proteins in the brain of people with ALS and related conditions, to find clues for better treatments.
-
Determinants of Pathogenic Anti-PF4 Antibody–Mediated Platelet Activation
This project looks at why certain anti-PF4 antibodies in people cause harmful blood clots and how to better diagnose and treat those cases.
-
Understanding how a type of immune cell called ILC2s affect asthma in adults
This grant studies how group 2 innate lymphoid cells influence asthma in adults to help identify new ways to manage airway inflammation.
-
EHMT1 Variants and Kleefstra Syndrome: How Structure Shapes Neurodevelopmental Risks
A small NIH grant will explore how genetic changes in EHMT1 affect brain development in Kleefstra Syndrome using computer models and analysis of protein structure.
-
Targeting epigenomic regulators to assault pancreatic cancer replication stress
This research tests a new way to treat pancreatic cancer by blocking key epigenetic regulators during DNA replication to make cancer cells less able to cope with replication stress.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.