Creating advanced cell therapies to improve treatment outcomes for chronic diseases
Engineering cell-based therapy for enhanced survival and durable function in vivo
This study is exploring new ways to use specially engineered cells to create lasting treatments for conditions like hemophilia, diabetes, and liver disorders, so patients can enjoy better health without needing constant therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-11143150 on NIH RePORTER |
What this research studies
This research focuses on developing innovative cell-based therapies that can provide long-lasting treatment for chronic conditions like hemophilia, diabetes, and liver disorders. The approach involves engineering cells that can secrete therapeutic proteins and encapsulating them to protect against the body's immune response. By addressing challenges such as immune activation and cellular dysfunction, the research aims to create a reliable method for transplanting these engineered cells without the need for systemic immunosuppression. Patients may benefit from a more effective and durable treatment option that could reduce the need for ongoing therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic diseases such as hemophilia, diabetes, or liver disorders who may benefit from advanced cell-based therapies.
Not a fit: Patients with acute conditions or those who do not have chronic diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and long-lasting treatments for chronic diseases, improving patients' quality of life.
How similar studies have performed: While there has been significant research in cell-based therapies, this specific approach of combining engineered cells with encapsulation to enhance long-term function is relatively novel and has not yet been fully realized in humans.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Bose, Suman — Mayo Clinic Arizona
- Study coordinator: Bose, Suman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.