Creating advanced biosensors to track protein modifications
Machine-Learning Aided Design of Avidity-Based Biosensors of Ubiquitin Signaling
['FUNDING_R01'] · COLORADO STATE UNIVERSITY · NIH-11081023
This study is working on creating smart sensors that can track important changes in proteins related to diseases like cancer, helping researchers understand how these proteins behave in real-time, which could lead to better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLORADO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (FORT COLLINS, UNITED STATES) |
| Trial ID | NIH-11081023 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative biosensors that can monitor specific changes in proteins, particularly those modified by ubiquitin. By utilizing machine-learning techniques, the team aims to design sensors that can detect and analyze the dynamics and abundance of these modifications in real-time. The project will involve engineering proteins to enhance their ability to bind to target molecules, making it easier to study complex biological processes. Patients may benefit from improved understanding of protein signaling related to various diseases, including cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein signaling abnormalities, such as certain cancers.
Not a fit: Patients with conditions unrelated to protein modifications or those not requiring advanced biosensor technology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for diseases linked to protein modifications.
How similar studies have performed: Previous research has shown promise in using biosensors for monitoring protein modifications, indicating a potential for success with this novel approach.
Where this research is happening
FORT COLLINS, UNITED STATES
- COLORADO STATE UNIVERSITY — FORT COLLINS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAO, TINGTING — COLORADO STATE UNIVERSITY
- Study coordinator: YAO, TINGTING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.