Creating advanced biosensors to track protein modifications
Official title: Machine-Learning Aided Design of Avidity-Based Biosensors of Ubiquitin Signaling
Funded at Colorado State University · NIH-11081023 · Data updated 2026-11-12
This study is working on creating smart sensors that can track important changes in proteins related to diseases like cancer, helping researchers understand how these proteins behave in real-time, which could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $419,958 |
| NIH project number | 5R01CA283904-02 |
| Project ID | NIH-11081023 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein signaling abnormalities, such as certain cancers.
✕Less likely to help
Patients with conditions unrelated to protein modifications or those not requiring advanced biosensor technology may not benefit from this research.
What this research studies
This research focuses on developing innovative biosensors that can monitor specific changes in proteins, particularly those modified by ubiquitin. By utilizing machine-learning techniques, the team aims to design sensors that can detect and analyze the dynamics and abundance of these modifications in real-time. The project will involve engineering proteins to enhance their ability to bind to target molecules, making it easier to study complex biological processes. Patients may benefit from improved understanding of protein signaling related to various diseases, including cancer.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for diseases linked to protein modifications.
How similar studies have gone: Previous research has shown promise in using biosensors for monitoring protein modifications, indicating a potential for success with this novel approach.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Yao, Tingting — Colorado State University
- Study coordinator: Yao, Tingting
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.