Creating advanced biosensors to improve CAR T cell therapy for cancer treatment
Development of single fluorophore biosensors for multiplex imaging of CAR T Signaling
['FUNDING_CAREER'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11032890
This study is working on creating special tools to see how CAR T cells act in real-time, helping us understand why they sometimes stop working in solid tumors, with the hope of making cancer treatments better for patients like you.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11032890 on ClinicalTrials.gov |
What this research studies
This research focuses on developing highly sensitive biosensors that can visualize the signaling activities of CAR T cells in real-time. By using advanced techniques in mammalian cells, the project aims to understand the molecular mechanisms that lead to T cell exhaustion in solid tumors. The goal is to enhance the effectiveness of CAR T cell therapy by identifying and manipulating key regulatory proteins and epigenetic markers involved in T cell function. Patients may benefit from improved cancer immunotherapy strategies that arise from these insights.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing CAR T cell therapy for solid tumors who may experience T cell exhaustion.
Not a fit: Patients with cancers that do not involve CAR T cell therapy or those who are not eligible for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective CAR T cell therapies, potentially improving outcomes for cancer patients.
How similar studies have performed: Previous research has shown promise in using biosensors for cellular imaging, indicating that this approach could yield valuable insights into CAR T cell dynamics.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, LONGWEI — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: LIU, LONGWEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer immunotherapy, anti-cancer therapy, anticancer immunotherapy