Creating advanced antibody libraries for cancer protein detection
Official title: Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries
Funded at Broad Institute, INC. · NIH-10903802 · Data updated 2026-11-12
This study is working on new ways to create a big collection of special proteins called antibodies that can help find cancer proteins, which could lead to better tests and treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | August 9, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $210,516 |
| NIH project number | 5R61CA281807-02 |
| Project ID | NIH-10903802 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with various types of cancer who may benefit from advanced diagnostic techniques.
✕Less likely to help
Patients with non-cancerous conditions or those not involved in cancer research may not receive direct benefits from this research.
What this research studies
This research focuses on developing innovative methods to create large-scale libraries of antibodies that can detect various cancer proteins. By engineering synthetic nanobodies, the project aims to enable high-dimensional analysis of proteins through techniques like spatially-indexed sequencing and targeted proteomics. Patients may benefit from improved diagnostic tools and therapies as these methods could enhance our understanding of cancer biology and treatment responses. The approach is designed to be scalable and cost-effective, making it accessible for widespread use in cancer research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and efficient cancer diagnostics and targeted therapies.
How similar studies have gone: Other research has shown success with similar antibody engineering approaches, indicating potential for impactful advancements in cancer diagnostics.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Hacohen, Nir — Broad Institute, INC.
- Study coordinator: Hacohen, Nir
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.