Creating advanced 3D tissue models using new scaffold technology
Official title: Development of Cell Culture Inserts and 3D In Vitro Tissue Models Utilizing Novel Electrospun Scaffolds
Funded at Biosurfaces · NIH-10843164 · Data updated 2026-11-12
This study is working on creating better lab models that mimic real human tissues more closely, which could lead to safer and more effective drug testing without using animals, ultimately benefiting patients like you.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biosurfaces NIH-funded |
| Lab location | 1 site (Ashland, United States) |
| Project start | May 17, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $840,696 |
| NIH project number | 5R44ES034681-02 |
| Project ID | NIH-10843164 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals interested in the development of safer pharmaceuticals and those affected by conditions requiring innovative treatment testing.
✕Less likely to help
Patients who are not involved in drug development or who do not have conditions that require new treatment testing may not receive direct benefits from this research.
What this research studies
This research focuses on developing innovative tissue culture inserts that utilize 3D electrospun scaffolds to create more realistic in vitro tissue models. These models aim to replace outdated 2D scaffolds that do not accurately mimic the natural extracellular matrix, which is crucial for studying human tissues. By improving the design and functionality of these scaffolds, the research seeks to enhance the physiological relevance of tissue models used in drug testing and toxicity assessments. Patients may benefit from more effective and humane testing methods that do not rely on animal models.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and ethical testing methods for new drugs and treatments, ultimately improving patient safety and outcomes.
How similar studies have gone: Previous research has shown promise in using advanced scaffold technologies for tissue modeling, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
-
Biosurfaces
Ashland, United States Active
Researchers
- Principal investigator: Hayden, Patrick J — Biosurfaces
- Study coordinator: Hayden, Patrick J
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.