Creating advanced 3D models to study lung fibrosis
Hybrid Hydrogel Biomaterials Comprising Clickable Decellularized Extracellular Matrix for Engineering Dynamic 3D Models of Fibrosis
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-10886013
This study is working on creating special materials that act like the natural environment of our cells to help scientists learn more about idiopathic pulmonary fibrosis (IPF) and find better treatments for it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10886013 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative hybrid hydrogel biomaterials that mimic the extracellular matrix to create dynamic 3D models for studying idiopathic pulmonary fibrosis (IPF). By utilizing these models, researchers aim to better understand the complex interactions between cells and their environment, which are crucial for the progression of fibrosis. The approach involves synthesizing and microfabricating materials that can replicate the mechanical properties and cellular interactions found in human tissues. This could lead to the identification of new therapeutic targets for IPF, ultimately improving treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with idiopathic pulmonary fibrosis or those at risk of developing this condition.
Not a fit: Patients with fibrotic disorders other than idiopathic pulmonary fibrosis may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that halt or reverse the progression of idiopathic pulmonary fibrosis.
How similar studies have performed: Previous research has shown promise in using advanced biomaterials for modeling diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAGIN, CHELSEA M — UNIVERSITY OF COLORADO DENVER
- Study coordinator: MAGIN, CHELSEA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.