Creating advanced 3D human organ models for testing drug safety
Engineering multifaceted 3D human organ platforms for toxicity testing
This study is working on creating special 3D models of human organs that act like our heart and blood vessels to help test new medicines more accurately and reduce the need for animal testing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10896218 on NIH RePORTER |
What this research studies
This research focuses on developing innovative 3D human organ platforms that mimic the cardiovascular system to improve drug testing and reduce reliance on animal models. By creating microphysiological systems that replicate the interactions between different types of human cells, the project aims to enhance our understanding of how drugs affect human tissues. The approach involves using advanced fabrication techniques to create these models, allowing for better control of environmental conditions and more accurate testing outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the development of safer pharmaceuticals and those affected by cardiovascular conditions.
Not a fit: Patients who are not affected by cardiovascular issues or are not involved in drug development may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective drugs by providing better testing methods that reflect human biology.
How similar studies have performed: Other research has shown promise in using 3D organ models for drug testing, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Koppes, Ryan Alan — Northeastern University
- Study coordinator: Koppes, Ryan Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.