Creating a vaccine to prevent Chlamydia infections
Official title: Development of a recombinant protein vaccine for Chlamydia trachomatis
Funded at Univ of North Carolina Chapel Hill · NIH-11061077 · Data updated 2026-11-12
This study is working on a new vaccine to help protect against Chlamydia, a common infection that can affect reproductive health, by using a special protein from the bacteria to boost your immune system, and it’s designed to be given through the nose for better protection.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | May 10, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,925,693 |
| NIH project number | 5U01AI182180-02 |
| Project ID | NIH-11061077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are sexually active women who are at risk of Chlamydia infections.
✕Less likely to help
Patients who are not sexually active or those who have already been vaccinated against Chlamydia may not benefit from this research.
What this research studies
This research focuses on developing a vaccine against Chlamydia trachomatis, a bacterium that causes significant reproductive health issues. The approach involves using a specific protein from the bacterium, combined with powerful adjuvants, to stimulate the immune system effectively. By targeting both T cells and B cells, the vaccine aims to provide robust protection against the infection. The research includes innovative methods of delivering the vaccine intranasally to enhance immune response in the female genital tract.
Why it matters
Potential benefit: If successful, this research could lead to a vaccine that significantly reduces the incidence of Chlamydia infections and their associated reproductive complications.
How similar studies have gone: Previous research has shown promise in developing vaccines for other sexually transmitted infections, indicating potential success for this novel approach.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Darville, Toni — Univ of North Carolina Chapel Hill
- Study coordinator: Darville, Toni
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.