Creating a urine test to detect non-muscle-invasive bladder cancer
Official title: Development of a Urine Genetic Test for NonMuscle Invasive Bladder Cancer
Funded at Jbs Science, INC. · NIH-10759106 · Data updated 2026-11-12
This study is working on a new urine test that looks at genetic information to help people with non-muscle-invasive bladder cancer get better treatment and monitor their condition more effectively.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jbs Science, INC. NIH-funded |
| Lab location | 1 site (Doylestown, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $406,500 |
| NIH project number | 1R43HG013476-01 |
| Project ID | NIH-10759106 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-muscle-invasive bladder cancer who require ongoing monitoring and treatment guidance.
✕Less likely to help
Patients with muscle-invasive bladder cancer or those without a diagnosis of bladder cancer may not benefit from this research.
What this research studies
This research focuses on developing a urine genetic test specifically for non-muscle-invasive bladder cancer (NMIBC), which is a common type of bladder cancer. The test aims to provide comprehensive genetic information that can help guide treatment decisions and monitor for recurrence. By analyzing tumor cells and cell-free DNA in urine, the researchers hope to improve the accuracy of diagnosis and treatment stratification for patients with NMIBC. This innovative approach addresses the current limitations in distinguishing between NMIBC and muscle-invasive bladder cancer.
Why it matters
Potential benefit: If successful, this research could lead to a more accurate and less invasive method for diagnosing and monitoring bladder cancer, ultimately improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using genetic testing for cancer diagnosis, indicating that this approach may lead to significant advancements in bladder cancer management.
Where this research is happening
-
Jbs Science, INC.
Doylestown, United States Active
Researchers
- Principal investigator: Lin, Selena — Jbs Science, INC.
- Study coordinator: Lin, Selena
Related research
Other NIH-funded projects on the same topics.
-
Population modeling to reduce bladder cancer burden
Aimed at predicting and guiding effective, population-based ways to prevent and control bladder cancer.
-
Blocking a new immune checkpoint in bladder cancer
Researchers are trying medicines that block a newly found immune pathway to help people with bladder cancer, especially those whose tumors do not respond to current immunotherapy.
-
Nrf2 in T cells and how it could boost immune power against bladder cancer
A small grant will explore how a T-cell protein called Nrf2 affects muscle-invasive bladder cancer and whether targeting it could help patients respond better to immune therapies.
-
Understanding why bladder cancer spreads and resists treatment
This grant studies how advanced bladder cancer changes and spreads across the body, aiming to uncover why it’s hard to treat.
-
Molecular clues to bladder cancer cell changes and therapy response
This NIH grant looks at how bladder cancer cells change their identity and how that affects response to treatment, with a focus on aggressive neuroendocrine variants.
-
Repurposing spironolactone to treat bladder cancer inside the bladder
Aims to repurpose spironolactone as an intravesical treatment for non-muscle invasive bladder cancer to help prevent recurrence and progression.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.