Creating a tool to understand how skin absorbs topical medications
Development and Validation of a Multi-functional, Multi-purpose Quantitative Tool for Dermal Physiologically-Based Pharmacokinetic Modeling
This study is working on a new tool to better understand how skin absorbs creams and ointments, which could help create more effective treatments for people using these types of medications.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Bath NIH-funded |
| Lab location | 1 site (Bath, United Kingdom) |
| Project ID | NIH-10928221 on NIH RePORTER |
What this research studies
This research focuses on developing a new quantitative tool that models how topical medications are absorbed by the skin. It investigates the changes that occur when these products are applied, including the evaporation of certain ingredients and how the remaining film on the skin affects drug delivery. By using both new and existing experimental data, the project aims to enhance an existing model that simulates drug absorption, making it more accurate in predicting how medications interact with skin. This could lead to better formulations and improved therapeutic outcomes for patients using topical treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals who use topical medications for various skin conditions.
Not a fit: Patients who do not use topical medications or have conditions that require systemic treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective topical medications that are better absorbed by the skin, improving treatment outcomes for patients.
How similar studies have performed: While the approach of using physiologically-based pharmacokinetic modeling is established, the specific application to dermal metamorphosis is innovative and has not been extensively tested.
Where this research is happening
Bath, United Kingdom
- University of Bath — Bath, United Kingdom (Active)
Researchers
- Principal investigator: Delgado-Charro, M. Begona — University of Bath
- Study coordinator: Delgado-Charro, M. Begona
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.