Creating a test to detect long-term damage from radiation exposure
Development of a minimally invasive biomarker assay to detect delayed radiation injury
['FUNDING_U01'] · UNIV OF ARKANSAS FOR MED SCIS · NIH-10766742
This study is looking to create a simple test that can spot early signs of damage to organs like the kidney, heart, and brain from radiation exposure, helping doctors diagnose and treat people sooner before any symptoms show up.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF ARKANSAS FOR MED SCIS (nih funded) |
| Locations | 1 site (LITTLE ROCK, UNITED STATES) |
| Trial ID | NIH-10766742 on ClinicalTrials.gov |
What this research studies
This research aims to develop a minimally invasive biomarker assay that can identify delayed radiation injuries in organs such as the kidney, heart, and brain. By analyzing biofluids like plasma and urine, the study seeks to discover specific metabolic markers that indicate radiation exposure before clinical symptoms appear. The approach involves using established animal models to validate these biomarkers and create a scoring algorithm for predicting organ damage. This could lead to earlier diagnosis and improved treatment options for individuals exposed to ionizing radiation.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have been exposed to ionizing radiation due to events such as nuclear warfare, terrorism, or radiological accidents.
Not a fit: Patients who have not been exposed to ionizing radiation or who are not at risk of such exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable earlier detection of radiation-induced injuries, leading to better patient outcomes and targeted therapies.
How similar studies have performed: While the approach of developing biomarkers for radiation injury is innovative, similar research has shown promise in identifying biomarkers for other types of injuries and diseases.
Where this research is happening
LITTLE ROCK, UNITED STATES
- UNIV OF ARKANSAS FOR MED SCIS — LITTLE ROCK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOERMA, MARJAN — UNIV OF ARKANSAS FOR MED SCIS
- Study coordinator: BOERMA, MARJAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.