Creating a targeted treatment for colorectal cancer using radiotherapy
Development of an NTSR1-Targeted Radiotherapeutic for Colorectal Cancer
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-11045741
This study is testing a new way to treat colorectal cancer by using a special type of radiation that targets cancer cells more precisely, which could help improve treatment for patients at different stages of the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-11045741 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new treatment for colorectal cancer that uses targeted radionuclide therapy (TRT) to specifically attack cancer cells. By designing agents that target the neurotensin receptor subtype 1 (NTSR1), which is commonly overexpressed in colorectal cancer patients, the goal is to enhance the effectiveness of radiation therapy. The approach involves creating low-molecular-weight agents that can remain in the tumor longer, thereby delivering a higher dose of radiation to cancer cells while minimizing exposure to healthy tissues. This innovative method aims to improve treatment outcomes for patients at various stages of colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer, particularly those with tumors expressing the NTSR1 receptor.
Not a fit: Patients with colorectal cancer who do not express the NTSR1 receptor may not benefit from this targeted treatment approach.
Why it matters
Potential benefit: If successful, this research could provide a more effective treatment option for colorectal cancer patients, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in using targeted radionuclide therapies for cancer treatment, indicating that this approach could be effective.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARRISON, JERED C — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: GARRISON, JERED C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.