Creating a system to study heart cell communication after a heart attack
Engineering a Microphysiological System to Model the Infarct Border Zone and Interrogate Oxygen-Dependent Cell-Cell Communication in the Myocardium
This study is looking at how heart cells talk to each other after a heart attack, especially when there's not enough oxygen, to find better ways to prevent heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10817166 on NIH RePORTER |
What this research studies
This research investigates how heart cells communicate with each other in the aftermath of a heart attack, particularly focusing on the effects of low oxygen levels. By engineering a microphysiological system that mimics the conditions of the heart after an infarction, the study aims to explore how different types of heart cells interact through exosomes, which are small particles that carry signals between cells. This approach allows for a more accurate representation of the oxygen gradients present in the heart post-infarction, enabling researchers to better understand the cellular responses and potential therapeutic targets for preventing heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction or are at risk for heart failure.
Not a fit: Patients with non-cardiac conditions or those who have not experienced a heart attack may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and reduce the risk of heart failure after a heart attack.
How similar studies have performed: Other research has shown promise in understanding cell communication in cardiac contexts, but this specific approach using a microphysiological system is relatively novel.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Mccain, Megan Laura — University of Southern California
- Study coordinator: Mccain, Megan Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.