Creating a system to safeguard and enhance large DNA for genome analysis
Official title: Development of a system to protect and concentrate large DNA for genome analysis
Funded at University of Nebraska Kearney · NIH-10973924 · Data updated 2026-11-12
This study is working on a new way to better protect and study large pieces of DNA, which can help us understand complex genetic diseases like Charcot-Marie-Tooth and some cancers, starting with simpler organisms before moving on to more complicated ones.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Kearney NIH-funded |
| Lab location | 1 site (Kearney, United States) |
| Project start | August 6, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $394,857 |
| NIH project number | 1R15GM155799-01 |
| Project ID | NIH-10973924 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions linked to structural variations in their DNA, such as Charcot-Marie-Tooth disease or certain cancers.
✕Less likely to help
Patients with conditions not related to structural variations in DNA may not benefit from this research.
What this research studies
This research focuses on developing a method to protect and concentrate large DNA molecules, which is crucial for analyzing complex genetic diseases. By utilizing long molecule read lengths, the project aims to improve the understanding of structural variations in the genome that are linked to various diseases, including Charcot-Marie-Tooth and certain cancers. The approach involves testing the system with simpler organisms like yeast before applying it to more complex samples. This could lead to better identification of genetic variants and disease mechanisms.
Why it matters
Potential benefit: If successful, this research could significantly enhance the ability to analyze genetic variations associated with complex diseases, leading to improved diagnostics and treatment options.
How similar studies have gone: Other research has shown promise in utilizing long DNA reads for genetic analysis, indicating that this approach could be effective.
Where this research is happening
-
University of Nebraska Kearney
Kearney, United States Active
Researchers
- Principal investigator: Kounovsky-Shafer, Kristy — University of Nebraska Kearney
- Study coordinator: Kounovsky-Shafer, Kristy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.