Creating a system to safeguard and enhance large DNA for genome analysis
Development of a system to protect and concentrate large DNA for genome analysis
This study is working on a new way to better protect and study large pieces of DNA, which can help us understand complex genetic diseases like Charcot-Marie-Tooth and some cancers, starting with simpler organisms before moving on to more complicated ones.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Kearney NIH-funded |
| Lab location | 1 site (Kearney, United States) |
| Project ID | NIH-10973924 on NIH RePORTER |
What this research studies
This research focuses on developing a method to protect and concentrate large DNA molecules, which is crucial for analyzing complex genetic diseases. By utilizing long molecule read lengths, the project aims to improve the understanding of structural variations in the genome that are linked to various diseases, including Charcot-Marie-Tooth and certain cancers. The approach involves testing the system with simpler organisms like yeast before applying it to more complex samples. This could lead to better identification of genetic variants and disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions linked to structural variations in their DNA, such as Charcot-Marie-Tooth disease or certain cancers.
Not a fit: Patients with conditions not related to structural variations in DNA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly enhance the ability to analyze genetic variations associated with complex diseases, leading to improved diagnostics and treatment options.
How similar studies have performed: Other research has shown promise in utilizing long DNA reads for genetic analysis, indicating that this approach could be effective.
Where this research is happening
Kearney, United States
- University of Nebraska Kearney — Kearney, United States (Active)
Researchers
- Principal investigator: Kounovsky-Shafer, Kristy — University of Nebraska Kearney
- Study coordinator: Kounovsky-Shafer, Kristy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.