Creating a system to measure pain in newborns using AI technology

Developing AI-Driven Pain Intensity and Pain Sensitization Biomarker Signatures to Optimize Neonatal Pain Management

NIH-funded research University of South Florida · NIH-10973901

This study is working on a smart system that helps doctors and nurses better understand when newborns in the NICU are in pain, so they can use safer treatments and keep these little ones healthier during tough times.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of South Florida NIH-funded
Lab location1 site (Tampa, United States)
Project IDNIH-10973901 on NIH RePORTER

What this research studies

This research focuses on improving pain management for newborns in the neonatal intensive care unit (NICU) by developing an automated system that uses artificial intelligence to continuously monitor pain levels. The goal is to identify pain early, allowing healthcare providers to use non-opioid treatments and reduce the need for opioids, which can have harmful long-term effects on brain development. By utilizing biomarkers, the system aims to provide objective and reliable pain assessments, addressing the challenges of subjective evaluations currently used by nurses. This innovative approach seeks to enhance the overall care and outcomes for vulnerable infants undergoing painful procedures.

Who could benefit from this research

Good fit: Ideal candidates for this research are newborns aged 0-4 weeks who are undergoing invasive procedures or surgeries in the NICU.

Not a fit: Patients who are not in the NICU or those who do not require pain management interventions will likely not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better pain management strategies for newborns, reducing their exposure to harmful opioids and improving their long-term neurodevelopmental outcomes.

How similar studies have performed: While the approach of using AI for pain monitoring in neonates is innovative, similar methodologies in other areas of pain management have shown promising results.

Where this research is happening

Tampa, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.