Creating a system to assess drug risks to developing hearts using 3D models.
Establishing an In Vitro Embryotoxicity Risk Classification System Based on Human Cardiac Organoid Model
['FUNDING_R01'] · SYRACUSE UNIVERSITY · NIH-10796785
This study is looking at how different medications might affect the heart development of babies during pregnancy by using a special 3D model made from human heart cells, so that doctors can better understand which drugs are safe for expectant moms and their little ones.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SYRACUSE UNIVERSITY (nih funded) |
| Locations | 1 site (SYRACUSE, UNITED STATES) |
| Trial ID | NIH-10796785 on ClinicalTrials.gov |
What this research studies
This research aims to develop a new method for evaluating the safety of medications during pregnancy by using a 3D model of human heart tissue created from stem cells. The researchers will focus on how different drugs affect the growth and development of these heart organoids, which closely mimic real human heart development. By establishing a risk classification system, the goal is to provide clearer insights into which drugs may pose risks to fetal heart development, ultimately improving safety for pregnant women and their babies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women or women planning to become pregnant who may be prescribed medications.
Not a fit: Patients who are not pregnant or not planning to become pregnant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer medication guidelines for pregnant women, reducing the risk of heart defects in their babies.
How similar studies have performed: Other research has shown promise in using 3D organoid models for drug testing, indicating that this approach could be effective.
Where this research is happening
SYRACUSE, UNITED STATES
- SYRACUSE UNIVERSITY — SYRACUSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MA, ZHEN — SYRACUSE UNIVERSITY
- Study coordinator: MA, ZHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.