Creating a system for assembling large DNA molecules
GenSyn: A Cycle for Serial Assembly of Very Large DNA Molecules
['FUNDING_R21'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10756447
This study is testing a new method to build large pieces of DNA without using living cells, which could help scientists better understand genes and improve health-related applications.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10756447 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new system called GenSyn that allows for the direct and validated assembly of very large DNA molecules without the need for living cells. By utilizing innovative binding techniques and fluidic operations, the project aims to enhance the efficiency of DNA assembly processes. The approach includes optimizing hybridization and ligation steps, and using advanced imaging techniques to monitor the assembly of DNA constructs. This work could significantly improve our understanding of genomes and their applications in health.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals interested in genetic therapies or those with conditions that could benefit from advancements in genome assembly.
Not a fit: Patients with conditions unrelated to genetic therapies or those not involved in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more efficient methods for assembling large DNA sequences, which may enhance genetic research and therapeutic applications.
How similar studies have performed: Other research has shown promise in similar approaches to DNA assembly, indicating potential for success in this novel application.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHWARTZ, DAVID C. — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: SCHWARTZ, DAVID C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.