Creating a safer and more effective treatment for opioid use disorder using a new ibogaine analog.

Who could benefit from this research

What this research studies

This research focuses on developing a new synthetic version of ibogaine, called GM-3009, to treat opioid use disorder (OUD). Ibogaine has shown potential in helping individuals overcome opioid dependence, but its use has been limited due to safety concerns, particularly related to heart and brain toxicity. The research aims to conduct preclinical studies to ensure GM-3009 is safe and effective, followed by clinical trials to test its safety and efficacy in humans. Patients may benefit from a new treatment option that could help reduce withdrawal symptoms and improve abstinence rates.

Why it matters

Where this research is happening

• Gilgamesh Pharmaceuticals INC
  New York, United States Active

Researchers

• Principal investigator: Marek, Gerard Joseph — Gilgamesh Pharmaceuticals INC
• Study coordinator: Marek, Gerard Joseph

Related research

Other NIH-funded projects on the same topics.

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  This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.

  NIH research Native American Community Clinic · Minneapolis, United States · NIH-11533803

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.