Creating a renewable human liver model to study liver infections
Developing a renewable and dissectible human liver for the study of HBV/HCV infection
This study is creating a new lab model of the human liver to help us learn more about how Hepatitis B and C viruses work, especially in people who have both infections, so we can find better ways to treat liver diseases caused by these viruses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10887549 on NIH RePORTER |
What this research studies
This research focuses on developing a renewable and dissectible human liver model to better understand infections caused by Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV). By using advanced 3D cell culture techniques, the project aims to replicate the complex interactions of these viruses within the liver, particularly in patients who are coinfected. The goal is to uncover the mechanisms that lead to severe liver diseases and to explore how these infections can be treated more effectively. Patients may benefit from insights gained through this innovative model that could lead to improved therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic HBV or HCV infections, particularly those who may be coinfected.
Not a fit: Patients who have already achieved a complete cure from HBV or HCV and do not have any liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from chronic liver diseases caused by HBV and HCV.
How similar studies have performed: Other research has shown promise in using 3D liver models to study viral infections, indicating that this approach could yield valuable insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Wu, Xianfang — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Wu, Xianfang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.