Creating a rabbit model to study myeloperoxidase deficiency
Official title: Development of a Rabbit Model for Myeloperoxidase Deficiency
Funded at Lsu Health Sciences Center · NIH-11126876 · Data updated 2026-11-12
This study is creating a special rabbit model to help us learn more about myeloperoxidase (MPO) deficiency, a condition that makes it harder for the immune system to fight infections, so we can better understand how it works and find new ways to help people with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | June 22, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $187,500 |
| NIH project number | 5R21AI185243-02 |
| Project ID | NIH-11126876 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with myeloperoxidase deficiency or those who experience recurrent fungal infections.
✕Less likely to help
Patients with conditions unrelated to myeloperoxidase deficiency or those who do not have a history of recurrent infections may not benefit from this research.
What this research studies
This research focuses on developing a rabbit model to better understand myeloperoxidase (MPO) deficiency, a condition that affects the immune system's ability to fight certain infections. By studying this model, researchers aim to uncover the underlying mechanisms of MPO deficiency and its role in various inflammatory diseases. The approach involves genetic manipulation and careful observation of the rabbits' immune responses to different pathogens. This work could provide insights into how MPO deficiency contributes to disease and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with myeloperoxidase deficiency and related inflammatory conditions.
How similar studies have gone: While the specific approach of using a rabbit model for MPO deficiency is novel, previous research has shown success in using animal models to study similar immune deficiencies and inflammatory diseases.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Wang, Guoshun — Lsu Health Sciences Center
- Study coordinator: Wang, Guoshun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.