Creating a quick test to monitor sickle cell disease through changes in red blood cells.
Official title: Development of POC system for patient condition and treatment monitoring in Sickle Cell Disease through hypoxia-induced sickling
Funded at Functional Fluidics, LLC · NIH-10820097 · Data updated 2026-11-12
This study is working on a quick and easy test to see how red blood cells change shape when there's not enough oxygen, which can help doctors understand how well treatments are working for people with sickle cell disease.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Functional Fluidics, LLC NIH-funded |
| Lab location | 1 site (Detroit, UNITED STATES) |
| Project start | September 20, 2024 |
| Project end | March 19, 2026 |
| Funding year | 2024 |
| Award (this year) | $265,347 |
| NIH project number | 1R43HL172384-01 |
| Project ID | NIH-10820097 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sickle cell disease who require ongoing treatment and monitoring.
✕Less likely to help
Patients without a diagnosis of sickle cell disease or those not undergoing treatment for this condition may not benefit from this research.
What this research studies
This research focuses on developing a rapid test that assesses how red blood cells change shape under low oxygen conditions, which can indicate the effectiveness of treatments for sickle cell disease (SCD). The test aims to be simple enough for use in clinics, allowing healthcare providers to monitor patients' conditions and treatment responses more effectively. By evaluating both long-term and immediate effects of therapies, this approach seeks to enhance personalized treatment plans for individuals with SCD. The goal is to create a user-friendly system that can be used in various healthcare settings, especially in areas where access to advanced medical facilities is limited.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and personalized treatment options for patients with sickle cell disease.
How similar studies have gone: While the approach of using hypoxia-induced sickling assays is innovative, similar methodologies have shown promise in other contexts, indicating potential for success.
Where this research is happening
-
Functional Fluidics, LLC
Detroit, United States Active
Researchers
- Principal investigator: Hines, Patrick — Functional Fluidics, LLC
- Study coordinator: Hines, Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.