Creating a platform to monitor how treatments affect pregnant individuals
Official title: Developing Extracellular Vesicle Based MPRINT Translational Resource Platform for Monitoring Therapeutics Response During Pregnancy
Funded at Ohio State University · NIH-10922779 · Data updated 2026-11-12
This study is looking to create a helpful tool that uses special markers from the placenta to see how well certain medications, like aspirin, work during pregnancy for those at risk of conditions like preeclampsia, by analyzing blood samples from pregnant individuals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 6, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $924,057 |
| NIH project number | 5R24HD113024-02 |
| Project ID | NIH-10922779 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant individuals, particularly those at risk for preeclampsia, who are receiving aspirin treatment.
✕Less likely to help
Patients who are not pregnant or lactating, or those who do not have any risk factors for pregnancy-related complications may not benefit from this research.
What this research studies
This research aims to develop a new resource platform that uses placental-specific biomarkers to monitor the response to therapeutic treatments during pregnancy. By analyzing extracellular vesicles found in maternal plasma, the study seeks to identify how these biomarkers correlate with the use of medications like aspirin in pregnant individuals at risk for conditions such as preeclampsia. The approach involves collecting and analyzing blood samples from participants to better understand the safety and efficacy of these treatments. This innovative methodology could lead to improved drug evaluation practices for pregnant and lactating individuals.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective therapeutic options for pregnant individuals, ultimately improving maternal and fetal health outcomes.
How similar studies have gone: Previous research has shown promise in using extracellular vesicles as biomarkers, indicating that this approach has potential for success.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Costantine, Maged — Ohio State University
- Study coordinator: Costantine, Maged
Related research
Other NIH-funded projects on the same topics.
-
How air pollution during pregnancy affects fetal growth over time
This study looks at how air pollution affects the growth of babies in the womb during pregnancy, using ultrasound images to track changes over time, and it aims to help expectant parents understand when their babies might be most at risk from pollution.
-
Postoperative Pain Guidelines for Pregnancy: Safer, Patient-Centered Opioid Use
We’re creating patient-friendly guidelines to help doctors manage pain after delivery and surgery in pregnant people, aiming to reduce opioid overuse and improve safety.
-
HPV and pregnancy risk: a big study following 1,280 pregnancies
A large pregnancy study at UTMB looks at whether human papillomavirus (HPV) during pregnancy is linked to problems like preterm birth.
-
Understanding how where you live and personal factors during pregnancy affect a child’s risk for obesity and metabolic problems
This project looks at how neighborhood conditions and individual factors during pregnancy may influence a child’s risk of obesity and metabolic health as they grow.
-
Blocking cancer-causing cMYC tricks after pregnancy changes in the breast
Researchers are testing how pregnancy and aging reshape the breast before cancer risk, using patient-reinformed models to see if it changes how dangerous cMYC signals behave.
-
SSRI use during pregnancy: effects on placental blood flow and inflammation
This grant studies how antidepressants (SSRIs) used during pregnancy might affect the placenta and inflammation, and whether a 5-HT2 receptor blocker could mitigate any negative effects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.