Creating a platform to monitor how treatments affect pregnant individuals
Developing Extracellular Vesicle Based MPRINT Translational Resource Platform for Monitoring Therapeutics Response During Pregnancy
This study is looking to create a helpful tool that uses special markers from the placenta to see how well certain medications, like aspirin, work during pregnancy for those at risk of conditions like preeclampsia, by analyzing blood samples from pregnant individuals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10922779 on NIH RePORTER |
What this research studies
This research aims to develop a new resource platform that uses placental-specific biomarkers to monitor the response to therapeutic treatments during pregnancy. By analyzing extracellular vesicles found in maternal plasma, the study seeks to identify how these biomarkers correlate with the use of medications like aspirin in pregnant individuals at risk for conditions such as preeclampsia. The approach involves collecting and analyzing blood samples from participants to better understand the safety and efficacy of these treatments. This innovative methodology could lead to improved drug evaluation practices for pregnant and lactating individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals, particularly those at risk for preeclampsia, who are receiving aspirin treatment.
Not a fit: Patients who are not pregnant or lactating, or those who do not have any risk factors for pregnancy-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective therapeutic options for pregnant individuals, ultimately improving maternal and fetal health outcomes.
How similar studies have performed: Previous research has shown promise in using extracellular vesicles as biomarkers, indicating that this approach has potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Costantine, Maged — Ohio State University
- Study coordinator: Costantine, Maged
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.