Creating a personalized medicine platform for treating pancreatic cancer based on circadian rhythms.
Development of a precision medicine platform for circadian based therapeutics in pancreatic cancer
This study is looking to create a personalized treatment plan for people with pancreatic cancer by using tiny models of their tumors to see how they might respond to different therapies, all while considering their body's natural rhythms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11119458 on NIH RePORTER |
What this research studies
This research focuses on developing a precision medicine platform that tailors treatments for pancreatic cancer by considering the body's circadian rhythms. It aims to utilize patient-derived organoids, which are miniature versions of tumors created from small tissue samples obtained through routine biopsies. By analyzing these organoids, researchers hope to predict how individual patients will respond to various therapies, thus enabling more effective and personalized treatment plans. This approach addresses the challenge of limited tumor tissue availability in pancreatic cancer patients, who often do not undergo surgery at diagnosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who are undergoing routine endoscopic biopsies.
Not a fit: Patients with pancreatic cancer who have already undergone surgical resection or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with pancreatic cancer.
How similar studies have performed: Other research has shown promise in using patient-derived organoids for personalized cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Bishehsari, Faraz — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Bishehsari, Faraz
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.