Creating a personalized medicine platform for treating pancreatic cancer based on circadian rhythms.
Official title: Development of a precision medicine platform for circadian based therapeutics in pancreatic cancer
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11119458 · Data updated 2026-11-12
This study is looking to create a personalized treatment plan for people with pancreatic cancer by using tiny models of their tumors to see how they might respond to different therapies, all while considering their body's natural rhythms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $798,207 |
| NIH project number | 7R01CA279487-03 |
| Project ID | NIH-11119458 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who are undergoing routine endoscopic biopsies.
✕Less likely to help
Patients with pancreatic cancer who have already undergone surgical resection or those with other types of cancer may not benefit from this research.
What this research studies
This research focuses on developing a precision medicine platform that tailors treatments for pancreatic cancer by considering the body's circadian rhythms. It aims to utilize patient-derived organoids, which are miniature versions of tumors created from small tissue samples obtained through routine biopsies. By analyzing these organoids, researchers hope to predict how individual patients will respond to various therapies, thus enabling more effective and personalized treatment plans. This approach addresses the challenge of limited tumor tissue availability in pancreatic cancer patients, who often do not undergo surgery at diagnosis.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with pancreatic cancer.
How similar studies have gone: Other research has shown promise in using patient-derived organoids for personalized cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Bishehsari, Faraz — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Bishehsari, Faraz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.