Creating a personalized lung model to study pulmonary fibrosis
Developing a patient-specific organoid model of pulmonary fibrosis using iPSCs
This study is creating a special lab model using cells from people with idiopathic pulmonary fibrosis to help us learn more about the disease and find better treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10745686 on NIH RePORTER |
What this research studies
This research focuses on developing a patient-specific organoid model to better understand idiopathic pulmonary fibrosis (IPF), a serious lung disease. By using induced pluripotent stem cells (iPSCs) from patients with pulmonary fibrosis, the researchers aim to create a 3D culture model that mimics lung epithelial cells. This model will allow for the investigation of how genetic factors and cellular changes contribute to the disease, potentially leading to new treatment strategies. The approach combines advanced cell culture techniques with insights from patient-specific biology.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with idiopathic pulmonary fibrosis, particularly those with known genetic mutations related to the disease.
Not a fit: Patients with other forms of lung disease or those without a diagnosis of pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pulmonary fibrosis by providing insights into disease mechanisms and potential therapeutic targets.
How similar studies have performed: Other research has shown promise in using organoid models for studying various diseases, suggesting that this approach could be effective for pulmonary fibrosis as well.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Kotton, Darrell N. — Boston University Medical Campus
- Study coordinator: Kotton, Darrell N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.