Creating a personalized liver model using patient cells
Official title: Validation of Patient-Specific, iPSC-based In Vitro Liver System
Funded at Southern Arizona VA Health Care System · NIH-10807535 · Data updated 2026-11-12
This study is creating a special model of your liver using your own cells to help doctors better understand liver diseases and find the best treatments just for you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Arizona VA Health Care System NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| NIH project number | 1I21BX005900-01A2 |
| Project ID | NIH-10807535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with liver diseases or conditions that affect liver function.
✕Less likely to help
Patients with non-liver related health issues or those who do not have access to the necessary medical facilities may not benefit from this research.
What this research studies
This research focuses on developing a patient-specific liver model using induced pluripotent stem cells (iPSCs). By taking cells from patients and converting them into liver cells, researchers aim to create a system that mimics the patient's own liver function. This model can be used to study liver diseases and test potential treatments in a controlled environment, providing insights that are directly relevant to individual patients. The approach combines advanced cell engineering techniques with biological modeling to enhance our understanding of liver conditions.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for liver diseases.
How similar studies have gone: Other research has shown promise in using iPSC technology for modeling diseases, indicating a potential for success in this novel approach.
Where this research is happening
-
Southern Arizona VA Health Care System
Tucson, United States Active
Researchers
- Principal investigator: Wertheim, Jason a — Southern Arizona VA Health Care System
- Study coordinator: Wertheim, Jason a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.