Creating a new way to produce circular RNAs using yeast
Development of circRNA manufacturing platform in yeast
This study is working on a new way to use yeast to make special RNA molecules called circular RNAs, which could help with treatments and tests for various health issues, making them easier to produce and use in medicine.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chimerna Therapeutics INC. NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10822799 on NIH RePORTER |
What this research studies
This research focuses on developing a manufacturing platform that uses yeast to produce high-quality circular RNAs (circRNAs), which are promising for therapeutic applications. The project aims to overcome current challenges in circRNA synthesis and purification, which have hindered their use in research and medicine. By leveraging a proprietary technology that enhances RNA expression and stability, the researchers hope to create a more efficient and effective method for producing these molecules. This could lead to improved availability of circRNAs for various applications, including diagnostics and therapeutics.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions that could be treated with therapies based on circRNAs.
Not a fit: Patients who are not affected by conditions that could be targeted by circRNA therapies may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a reliable source of circRNAs for therapeutic use, potentially leading to new treatments for various diseases.
How similar studies have performed: While the approach of using yeast for RNA production is innovative, similar technologies have shown promise in other contexts, suggesting potential for success.
Where this research is happening
New York, United States
- Chimerna Therapeutics INC. — New York, United States (Active)
Researchers
- Principal investigator: Pickering, Brian Frederick — Chimerna Therapeutics INC.
- Study coordinator: Pickering, Brian Frederick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.