Creating a new vaccine to help control HIV/AIDS
Development of an mRNA-Based Therapeutic HIV/AIDS Vaccine
This study is testing a new vaccine that uses mRNA to help your body fight HIV/AIDS better, so you might not need to take medication for the rest of your life, and it’s looking for people to join the trials to see how safe and effective it is.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10781941 on NIH RePORTER |
What this research studies
This research focuses on developing an mRNA-based therapeutic vaccine aimed at controlling HIV/AIDS without the need for lifelong antiretroviral therapy. The approach seeks to enhance the immune response, particularly targeting CD8+ T cells, to achieve a functional cure for HIV. By eliciting stronger and more effective immune responses, the goal is to reduce the viral load in patients and potentially eliminate the need for continuous medication. Patients may be involved in trials to assess the safety and efficacy of this innovative vaccine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and are interested in exploring new treatment options.
Not a fit: Patients who are not living with HIV or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a vaccine that allows individuals with HIV to control the virus without daily medication.
How similar studies have performed: While there have been promising developments in HIV vaccine research, this specific mRNA-based approach is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Okoye, Afamefuna — Oregon Health & Science University
- Study coordinator: Okoye, Afamefuna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.