Creating a new type of graft to repair pelvic organ prolapse
Official title: Development of a Novel Bioinspired Pelvic Organ Prolapse Repair Graft
Funded at University of Pittsburgh at Pittsburgh · NIH-10889142 · Data updated 2026-11-12
This study is working on a new type of graft to help fix pelvic organ prolapse, aiming to create a safe and effective solution that mimics healthy vaginal tissue, so patients can have better outcomes and fewer complications.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30HD108976-03 |
| Project ID | NIH-10889142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from pelvic organ prolapse who are seeking surgical repair options.
✕Less likely to help
Patients who do not have pelvic organ prolapse or those who are not candidates for surgical intervention may not benefit from this research.
What this research studies
This research focuses on developing a novel graft specifically designed to repair pelvic organ prolapse (POP), a condition that often leads to complications and reoperations. The approach involves studying the natural structure and function of healthy vaginal tissue to create a synthetic graft that mimics these properties. By utilizing advanced 3D printing techniques, the researchers aim to produce a biocompatible graft that supports cell adhesion and reduces the risk of failure. The project will also investigate how the mechanical and biochemical properties of the graft influence cellular behavior.
Why it matters
Potential benefit: If successful, this research could lead to more effective and durable treatments for pelvic organ prolapse, significantly improving patient outcomes.
How similar studies have gone: While there have been advancements in graft development for various surgical applications, this specific approach using bioinspired materials for pelvic organ prolapse repair is relatively novel.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Egnot, Morgan Lee — University of Pittsburgh at Pittsburgh
- Study coordinator: Egnot, Morgan Lee
Related research
Other NIH-funded projects on the same topics.
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Matrix Regenerative Nanotech to Slow Pelvic Organ Prolapse in Adults
A new nanoparticle-based treatment aims to slow pelvic organ prolapse in adults by reconnecting and strengthening elastic tissue to improve quality of life.
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Identifying early warning signs of pelvic organ prolapse in young women
This NIH grant aims to find early markers that signal risk of pelvic organ prolapse so we can prevent severe disease.
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New non-surgical option for treating pelvic organ prolapse
This study is testing a new, easy-to-use pessary for women over 50 with pelvic organ prolapse, designed to be more comfortable and simpler to insert and remove on their own.
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Developing a new adhesive to prevent pelvic organ prolapse in women
This study is working on a new, eco-friendly glue that can help women with early signs of vaginal wall detachment, which can lead to pelvic organ prolapse, by safely reattaching the vaginal wall to the pelvic muscles, aiming to prevent the need for surgery.
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Improving Uroflowmetry: Do Pre-Procedure Reminders Help Women Undergoing Urodynamics
This study tests whether sending reminder calls before a urodynamics test helps women with pelvic floor disorders feel more prepared and less anxious, and whether it makes the procedure go more smoothly.
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Vaginal Vault Support at Hysterectomy
This trial tests a new double-ligament vault suspension during hysterectomy to help prevent vaginal apex prolapse in women undergoing the procedure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.