Creating a new type of female contraceptive that targets sperm channels
Developing modulators of the sperm-specific potassium channel SLO3 for contraception
This study is working on a new type of birth control for women that doesn't use hormones and aims to stop sperm from fertilizing an egg, offering a safe and effective option with fewer side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10671550 on NIH RePORTER |
What this research studies
This research focuses on developing a non-hormonal contraceptive for women by targeting the sperm-specific potassium channel SLO3. The approach involves creating inhibitors that prevent sperm from undergoing essential processes needed for fertilization, without affecting other cells in the female body. The research aims to provide a highly effective contraceptive option that does not act as an abortifacient and has minimal side effects. By using high-throughput screening, the team will identify potential compounds that can serve as reversible contraceptives.
Who could benefit from this research
Good fit: Ideal candidates for this research are women seeking effective contraceptive methods that do not involve hormones or have abortifacient properties.
Not a fit: Patients who are not seeking contraceptive options or those who have medical conditions that contraindicate the use of contraceptives may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide women with a highly effective, non-hormonal contraceptive option that meets their needs without the risk of abortion.
How similar studies have performed: While targeting sperm channels for contraception is a novel approach, similar research has shown promise in developing non-hormonal contraceptives.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Santi, Celia M — Washington University
- Study coordinator: Santi, Celia M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.