Creating a new treatment to prevent opioid dependence
Official title: Development of a Novel Calcium Channel Therapeutic for Opioid Use Disorder
Funded at Vivreon Biosciences, LLC · NIH-11072769 · Data updated 2026-11-12
This study is testing a new non-opioid medication to help prevent patients from becoming dependent on opioids after their hospital stay, especially for those who have used opioids for a while during their treatment.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vivreon Biosciences, LLC NIH-funded |
| Lab location | 1 site (San Diego, UNITED STATES) |
| Project start | July 15, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,401,740 |
| NIH project number | 4R44DA058467-02 |
| Project ID | NIH-11072769 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are hospitalized patients who have received long-term opioid treatment for pain management.
✕Less likely to help
Patients who have not been exposed to opioids or those with existing opioid use disorder may not benefit from this research.
What this research studies
This research focuses on developing a novel non-opioid medication aimed at preventing opioid dependence in patients who have been exposed to opioids during hospitalization. The approach involves creating a small molecule therapeutic that targets calcium channels to mitigate the risk of developing opioid use disorder (OUD) after discharge. By addressing the underlying mechanisms of opioid dependence, the research seeks to improve patient outcomes and reduce the length of hospital stays. Patients who are at risk of opioid dependence due to prolonged opioid use will be the primary focus of this investigation.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of opioid use disorder among patients recovering from surgery or trauma.
How similar studies have gone: While the approach of developing non-opioid treatments is gaining traction, this specific therapeutic strategy is novel and has not been extensively tested in previous studies.
Where this research is happening
-
Vivreon Biosciences, LLC
San Diego, United States Active
Researchers
- Principal investigator: Greenberg, Milton L — Vivreon Biosciences, LLC
- Study coordinator: Greenberg, Milton L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.