Creating a new treatment for vision loss in older adults
Developing a novel disease-targeted anti-angiogenic therapy for CNV
This study is looking for a new way to help older adults with wet age-related macular degeneration (AMD) who aren't getting good results from current treatments, by creating special therapies that target specific factors causing vision problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10726508 on NIH RePORTER |
What this research studies
This research focuses on developing a novel therapy for wet age-related macular degeneration (AMD), a condition that causes significant vision loss in the elderly. The current treatments, which target vascular endothelial growth factor (VEGF), often have limited effectiveness and side effects. The researchers aim to identify specific angiogenic factors associated with choroidal neovascularization (CNV) and create targeted therapies that can improve outcomes for patients who do not respond well to existing treatments. By generating neutralizing monoclonal antibodies against these new targets, the study seeks to enhance the safety and efficacy of AMD treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with wet age-related macular degeneration who may not respond adequately to current therapies.
Not a fit: Patients with other forms of vision loss or those who do not have wet age-related macular degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients suffering from wet AMD, potentially preserving their vision.
How similar studies have performed: Other research has shown promise in developing targeted therapies for similar conditions, indicating potential for success in this novel approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Li, Wei — Baylor College of Medicine
- Study coordinator: Li, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.