Creating a new treatment for traumatic brain injury
Official title: Development of a novel peptide therapeutic for traumatic brain injury
Funded at Aivocode, LLP · NIH-10814998 · Data updated 2026-11-12
This study is testing a new treatment called CAQK to help people with moderate to severe traumatic brain injuries heal better and faster by giving it to them soon after the injury happens.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Aivocode, LLP NIH-funded |
| Lab location | 1 site (Encinitas, UNITED STATES) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,193,627 |
| NIH project number | 5R44NS130776-02 |
| Project ID | NIH-10814998 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced moderate to severe traumatic brain injuries.
✕Less likely to help
Patients with mild traumatic brain injuries or those who have not sustained a brain injury may not benefit from this research.
What this research studies
This research focuses on developing a novel peptide therapeutic called CAQK for treating moderate to severe traumatic brain injury (TBI). The approach involves administering this peptide early after the injury to limit secondary damage and promote healing. The research will conduct efficacy studies in pig models of TBI and generate pharmacokinetic profiles to understand how the treatment works in the body. The goal is to establish a new neuroprotective intervention that could significantly improve recovery outcomes for patients with TBI.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option that significantly improves recovery and healing for patients suffering from traumatic brain injuries.
How similar studies have gone: While the specific peptide CAQK is novel, similar approaches targeting secondary injury in TBI have shown promise in preclinical studies.
Where this research is happening
-
Aivocode, LLP
Encinitas, United States Active
Researchers
- Principal investigator: Mann, Aman — Aivocode, LLP
- Study coordinator: Mann, Aman
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.