Creating a new test to personalize treatment for pancreatic cancer
Developing ATAC-array as a novel epigenetic biomarker to guide personalized therapy in pancreatic cancer
This study is looking at a new way to understand pancreatic cancer by checking how accessible certain parts of the cancer cells are, which could help find markers that show how well someone might respond to chemotherapy, ultimately aiming to create more personalized treatment plans for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10512502 on NIH RePORTER |
What this research studies
This research focuses on developing a novel microarray platform called ATAC-array, which analyzes chromatin accessibility patterns in pancreatic cancer cells. By examining these patterns, researchers aim to identify specific biomarkers that can predict how well patients will respond to chemotherapy. The study involves using advanced genome-wide techniques to create a Prognosis Score that helps determine the best treatment options for individual patients. This approach could lead to more effective and personalized therapies for those diagnosed with pancreatic cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who are undergoing treatment.
Not a fit: Patients with pancreatic cancer who are not eligible for surgery or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve treatment outcomes for pancreatic cancer patients by tailoring therapies to their specific tumor characteristics.
How similar studies have performed: Other research has shown promise in using chromatin accessibility patterns for cancer prognosis, suggesting that this approach could be a valuable advancement in personalized medicine.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Leach, Steven D — Dartmouth College
- Study coordinator: Leach, Steven D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.