Creating a new test to diagnose silent brain injuries in older adults
Official title: Development and Validation of a Quantitative Diagnostic Biomarker for Silent Brain Injury
Funded at Sage Cerebrovascular Diagnostics, INC. · NIH-11007524 · Data updated 2026-11-12
This study is working on a new, easy test to help doctors find hidden brain injuries in older adults with Alzheimer's and similar conditions, which could lead to better treatment options for them.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sage Cerebrovascular Diagnostics, INC. NIH-funded |
| Lab location | 1 site (Calabasas, CA, UNITED STATES) |
| Project start | September 4, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $307,538 |
| NIH project number | 1R43NS139780-01 |
| Project ID | NIH-11007524 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who are experiencing symptoms of dementia or cognitive decline.
✕Less likely to help
Patients under the age of 65 or those without symptoms of cognitive impairment may not benefit from this research.
What this research studies
This research focuses on developing a new diagnostic tool to identify silent brain injuries, particularly in older adults suffering from Alzheimer's disease and related dementias. The approach involves a minimally invasive assay that measures specific inflammatory molecules linked to cerebrovascular injury. By improving diagnostic accuracy, this research aims to differentiate between Alzheimer's disease and vascular dementia, which can significantly impact treatment and care strategies for patients. The study will utilize a reliable immunoassay method to analyze these biomarkers, making it accessible and cost-effective compared to traditional MRI methods.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of dementia types, allowing for better-targeted treatments and improved patient outcomes.
How similar studies have gone: Previous research has shown promise in using biomarker assays for diagnosing various forms of dementia, indicating that this approach could be effective.
Where this research is happening
-
Sage Cerebrovascular Diagnostics, INC.
Calabasas, CA, United States Active
Researchers
- Principal investigator: Ebrahimzadeh Pustchi, Sadaf — Sage Cerebrovascular Diagnostics, INC.
- Study coordinator: Ebrahimzadeh Pustchi, Sadaf
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.