Creating a new system to analyze complex sugar structures on proteins
Official title: Development of a GBP-based glycosylation analysis system
Funded at Z Biotech, LLC · NIH-11066843 · Data updated 2026-11-12
This study is working on a new way to look at sugar changes on proteins and cells, which is important for understanding diseases like cancer and making better treatments, so if you're interested in how these sugars affect health, this research could help improve the tools we use to study them.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Z Biotech, LLC NIH-funded |
| Lab location | 1 site (Aurora, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $306,710 |
| NIH project number | 1R43GM157786-01 |
| Project ID | NIH-11066843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to glycosylation abnormalities, such as certain cancers or autoimmune diseases.
✕Less likely to help
Patients without any glycosylation-related conditions or those not involved in the research's target diseases may not benefit from this research.
What this research studies
This research focuses on developing a new system to analyze glycosylation, which refers to the complex sugar modifications on proteins and cells. These modifications are crucial for understanding diseases like cancer and improving therapeutic proteins. The project aims to enhance existing glycan binding assays and create software that automates the analysis of glycan structures, making it faster and more cost-effective. By collecting extensive data on glycan binding, the researchers hope to improve the accuracy of predictions regarding glycan structures.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for diseases influenced by glycosylation, such as cancer.
How similar studies have gone: Previous research has shown promise in glycan analysis techniques, indicating that this approach could build on existing successes in the field.
Where this research is happening
-
Z Biotech, LLC
Aurora, United States Active
Researchers
- Principal investigator: Zhang, Jian — Z Biotech, LLC
- Study coordinator: Zhang, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.