Creating a new salivary gland for patients with dry mouth after cancer treatment
Functional Biointegration of Bioengineered Salivary Tissues in Irradiated Animal Models
This study is working on creating a new type of implant that can help people with chronic dry mouth, especially those who have had radiation therapy for head and neck cancer, by restoring their saliva production to improve their oral health and overall quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10899702 on NIH RePORTER |
What this research studies
This research aims to develop a fully functional, implantable human salivary gland to help patients suffering from chronic dry mouth, known as xerostomia, which often occurs after radiation therapy for head and neck cancer. The team is using advanced animal models to test a patented tissue-engineered salivary tissue replacement called 3D-ST. By focusing on restoring both water secretion and essential proteins for digestion, the research seeks to improve oral health and quality of life for affected patients. The project involves collaboration among multiple research sites to ensure comprehensive testing and development.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have undergone radiation therapy for head and neck cancer and are experiencing xerostomia.
Not a fit: Patients who have not received radiation therapy or do not have head and neck cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for patients suffering from dry mouth, significantly improving their quality of life.
How similar studies have performed: Previous research has shown promise in using tissue-engineered solutions for similar conditions, indicating potential for success in this novel approach.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Farach-Carson, Mary C — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Farach-Carson, Mary C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.