Creating a new rat model to study brain blood vessel disease related to Alzheimer's
Novel Gene-Edited Rat Model for Development of CAA
This study is creating a special type of rat to help us learn more about cerebral amyloid angiopathy, a condition linked to Alzheimer's disease, so we can find better treatments for people affected by it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rhode Island NIH-funded |
| Lab location | 1 site (Kingston, United States) |
| Project ID | NIH-10574070 on NIH RePORTER |
What this research studies
This research focuses on developing a novel gene-edited rat model to better understand cerebral amyloid angiopathy (CAA), a condition that affects blood vessels in the brain and is commonly associated with Alzheimer's disease. By using advanced genetic editing techniques, the researchers aim to create a model that accurately reflects the human condition, allowing for more effective testing of potential treatments. The study will investigate how amyloid protein accumulates in the brain's blood vessels and leads to cognitive impairment and dementia. This approach seeks to overcome limitations of existing models that may not fully replicate the disease's pathology.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are elderly individuals, particularly those over 80 years old, who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients who are younger than 80 years or do not have any cognitive impairments related to Alzheimer's disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from Alzheimer's disease and related vascular cognitive impairments.
How similar studies have performed: Other research has shown success with gene-edited models in studying various diseases, suggesting that this approach could yield valuable insights into CAA and Alzheimer's disease.
Where this research is happening
Kingston, United States
- University of Rhode Island — Kingston, United States (Active)
Researchers
- Principal investigator: Van Nostrand, William E. — University of Rhode Island
- Study coordinator: Van Nostrand, William E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.