Creating a new platform to understand gene functions in diseases
Development of a platform for spatial functional genomics
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10877110
This study is creating a new tool to help scientists understand how different genes work in diseases like breast cancer, which could lead to better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10877110 on ClinicalTrials.gov |
What this research studies
This research aims to develop a groundbreaking platform for spatial functional genomics, which will allow scientists to investigate the roles of numerous genes in various diseases, including cancers like breast cancer. By using advanced techniques such as CRISPR, the project will enable the simultaneous alteration of multiple genes in tissues and tumors, helping to uncover how these changes affect biological processes at different levels. Patients may benefit from this research as it could lead to new insights into disease mechanisms and the development of targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or cancers, particularly those who may benefit from targeted therapies based on gene function.
Not a fit: Patients with well-defined genetic conditions that are already fully understood may not receive additional benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding and treating various diseases by identifying the specific roles of genes.
How similar studies have performed: Other research has shown promise in using CRISPR and functional genomics to explore gene functions, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROWN, BRIAN D — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: BROWN, BRIAN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.