Creating a new peptide to help relax blood vessels
Official title: Development of a Novel Vasorelaxing Peptide
Funded at Des Moines Univ Osteopathic Medical Ctr · NIH-10872534 · Data updated 2026-11-12
This study is testing a new treatment that helps your body make more nitric oxide to improve blood flow and relax your blood vessels, aiming to offer a better option for people with heart-related issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Des Moines Univ Osteopathic Medical Ctr NIH-funded |
| Lab location | 1 site (West Des Moines, United States) |
| Project start | May 6, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $453,404 |
| NIH project number | 1R15HL173818-01 |
| Project ID | NIH-10872534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from cardiovascular diseases or conditions that affect blood vessel function.
✕Less likely to help
Patients with non-cardiovascular related health issues or those who do not have any vascular complications may not benefit from this research.
What this research studies
This research focuses on developing a novel peptide that promotes the production of nitric oxide (NO) in the body, which is essential for relaxing blood vessels and improving blood flow. The study aims to address the limitations of current treatments for cardiovascular diseases, particularly those related to nitric oxide donors that can lead to tolerance and other complications. By targeting a specific protein involved in NO production, the researchers hope to create a more effective treatment option for patients with cardiovascular disorders. The approach involves both laboratory experiments and potential clinical applications to ensure the peptide's effectiveness and safety.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that improves blood vessel function and reduces complications in patients with cardiovascular diseases.
How similar studies have gone: While the approach of targeting endothelial STIM1 is novel, similar strategies in promoting endogenous NO production have shown promise in preliminary studies.
Where this research is happening
-
Des Moines Univ Osteopathic Medical Ctr
West Des Moines, United States Active
Researchers
- Principal investigator: Tran, Kim — Des Moines Univ Osteopathic Medical Ctr
- Study coordinator: Tran, Kim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.