Creating a new oral treatment for multiple coronaviruses
Development of an Oral Pan-Coronavirus Drug Cocktail
This study is looking for the best mix of antiviral medicines to help treat infections from different coronaviruses, like the one that causes COVID-19, so that we can have effective treatments ready for future outbreaks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10884228 on NIH RePORTER |
What this research studies
This research aims to develop a combination of antiviral drugs that can effectively treat infections caused by various coronaviruses, including SARS-CoV-2, the virus responsible for COVID-19. The approach involves identifying drug combinations that work synergistically to enhance their effectiveness against the virus. Researchers will use mathematical modeling to optimize dosing strategies and predict how these combinations will perform in humans. The goal is to create a proactive treatment option that can be rapidly deployed during future coronavirus outbreaks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently infected with coronaviruses, particularly those with COVID-19.
Not a fit: Patients who are not infected with coronaviruses or those who have conditions unrelated to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a powerful oral treatment option for patients infected with multiple coronaviruses, potentially reducing the severity and duration of illness.
How similar studies have performed: Previous research has shown promise in developing antiviral combinations for viral infections, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Polyak, Stephen J. — University of Washington
- Study coordinator: Polyak, Stephen J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.